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CX-5461 was administered orally at 50 mg/kg either once daily or every 3 days
SU5416 (25 mg/kg
potencies which may be expected for an ATP competitive inhibitor
InChi: InChI=1S/C23H33N5O2/c1-2-14-27-15-17-28(18-16-27)20-8-6-19(7-9-20)21(29)26-23(10-4-3-5-11-23)22(30)25-13-12-24/h6-9H
including LDL apheresis where available for the reduction of LDL-C
TEPP-46 (ML265) - Pyruvate Kinase M2 (PKM2) Activator. CAS# 1221186-53-3 60123 CX-5461 was administered orally atTEPP 46 (ML265), CAS No. 1221186 53 3, is a potent and selective Pyruvate kinase M2 (PKM2) activator with EC50 ~92 nM. It demonstrates >100 fold selectivity for PKM2 over the related PKM1, PKR, and PKL isoforms. It can stabilize pyruvate kinase subunit interactions, promote PKM2 tetramer formation and prevent inhibition by phosphotyrosine signaling. It can alter metabolism in cultured cells, and inhibit xenograft tumor growth in vivo. TEPP 46 inhibits
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