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1-2H3/t19-
[3] Combining Tipifarnib with 10 nM 4-OH-tamoxifen in the presence of E2 reduces the IC50 8-fold from 400 to 50 nM
It was approved by the US FDA in October 2012 for the treatment of adult patients with CML with resistance and/or intolerance to two or more tyrosine kinase inhibitors (TKIs)
21(10):968-80
It does not inhibit HDAC6 and HDAC8 (IC50 >100 µM)
PF-562271 hydrochloride Size:Contact [email protected] for quotation 1-2H3/t19-PF 562271 hydrochloride is a potent, ATP competitive and reversible FAK and Pyk2 kinase inhibitor with IC50s of 1. 5 nM and 13 nM, respectively. Product information CAS Number: 939791 41 0 Molecular Weight: 543. 95 Formula: C21H21ClF3N7O3S Chemical Name: N methyl N {3 [({2 [(2 oxo 2,3 dihydro 1H indol 5 yl)amino] 5 (trifluoromethyl)pyrimidin 4 yl}amino)methyl]pyridin 2 yl}methanesulfonamide hydrochloride Smiles: Cl.
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