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J Steroid Biochem Mol Biol
1186/s12974-015-0286-8
PubMed PMID: 12511611
Molecular Weight: 182
compared to 1
PF-04995274 0270 J Steroid Biochem Mol BiolPF 04995274 (PF 4995274) is a potent, high affinity, orally active and partial agonist of serotonin 4 receptor (5 HT4R) with EC50 of 0. 47 nM, 0. 36 nM, 0. 37 nM and 0. 26 nM for human 5 HT4A 4B 4D 4E, respectively. As for rat 5 HT4S 4L 4E, the EC50 is 0. 59 nM, 0. 65 nM and 0. 62 nM, respectively. PF 04995274 is brain penetrant and can be used for cognitive disorders associated with Alzheimer's disease. Product information CAS Number: 1331782 27 4
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