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InChi: InChI=1S/C14H14ClN3O2S/c1-8-4-3-5-10(9(8)2)16-12-6-11(15)17-14(18-12)21-7-13(19)20/h3-6H
which shows that PHT-427 could inhibit both Akt and PDPK1
2004 Nov 24
CAS Number: 179545-77-8
39(1):16-22
UK-370106 Size:Contact [email protected] for quotation InChi: InChI=1S/C14H14ClN3O2S/c1-8-4-3-5-10(9(8)2)16-12-6-11(15)17-14(18-12)21-7-13(19)20/h3-6HUK 370106 is a potent and highly selective MMP 3 (IC50 of 23 nM) and MMP 12 (IC50 of 42 nM) inhibitor with >1200 fold higher potency than MMP 1, MMP 2, MMP 9, and MMP 14, and about 100 fold than MMP 13 and MMP 8. UK 370106 potently inhibits cleavage of [3H] fibronectin by MMP 3 (IC50 of 320 nM) and has little effect on keratinocyte migration in vitro. Product information CAS Number: 230961 21 4 Molecular Weight: 572. 73 Formula: C35H44N2O5 Chemical
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