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ML-329 reduced the expression of multiple MITF target genes
VT-464 Size:Solid 2 mg ML-329 reduced the expression ofSeviteronel, also known as VT 464 and INO 464, is an orally available non steroidal, lyase selective inhibitor of the steroid 17 alpha hydroxylase C17,20 lyase (CYP17A1 or CYP17), with potential anti androgenic and antineoplastic activities. Upon oral administration, CYP17 inhibitor VT 464 selectively inhibits the enzymatic activity of the cytochrome P450 C17,20 lyase in both the testes and adrenal glands, thereby inhibiting androgen production.
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