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PubMed PMID: 8826855
YC-1 effectively inhibits tumor invasion and metastasis
selective inhibitor of the TGF-β type I receptor ALK5 with IC50 of 23 nM and 4 nM for ATP binding to ALK5 and ALK5 autophosphorylation
Abstract 3679
Formula: C28H26N4O4
ROC-325 - CAS# 1859141-26-6 size:2mg solid PubMed PMID: 8826855ROC 325, CAS No. 1859141 26 6, is an autophagy inhibitor. ROC 325 exhibited superior in vitro anticancer effects compared with the existing autophagy inhibitor hydroxychloroquine (HCQ) in 12 different cancer cell lines with diverse genetic backgrounds. ROC 325 antagonized RCC growth and survival in an ATG5 7 dependent manner, induced apoptosis, and exhibited favorable selectivity. Product information CAS Number: 1859141 26 6 Molecular Weight: 503. 06
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