OSI-027 - mTOR Inhibitor. CAS# 936890-98-1 Catalog No.:M60113-10S PubMed Central PMCID: PMC3870038

PubMed Central PMCID: PMC3870038

is approximately 40%

Bromberg J

34)/b23-17+

While nM concentrations of U0126 are efficient to reduce H1N1v and H5N1 (MB1)

OSI-027 - mTOR Inhibitor. CAS# 936890-98-1 Catalog No.:M60113-10S PubMed Central PMCID: PMC3870038OSI 027, CAS No. 936890 98 1, is a selective and potent dual inhibitor of mTORC1 and mTORC2 with IC50 of 22 nM and 65 nM, respectively. It shows more than 100 fold selectivity for mTOR relative to PI3K, PI3K, PI3K, and DNA PK. It inhibits phosphorylation of the mTORC1 substrates 4E BP1 and S6K1 as well as the mTORC2 substrate AKT in diverse cancer models in vitro and in vivo. OSI 027 shows robust antitumor activity in several different human xenograft